NORDITROPIN FlexPro 10mg/1.5ml . novo nordisk PEN


Manufacturer : NOVO NORDISK.

basic substance : somatropin.

package : 1PEN (10mg/1.5ml)

Category : HGH


NODITROPIN FlexPro is a premixed, preloaded pen that requires no reconstitution and no loading of cartridges.



NORDITROPIN FlexPro 10mg/1.5ml . novo nordisk PEN

Recombinant human growth hormone is used for the treatment of growth failure in children and metabolic dysfunction in adults with growth hormone deficiency. However, conventional growth hormone therapy requires /day  subcutaneous injections that may affect treatment adherence, and subsequently efficacy outcomes. To enhance potential treatment adherence, improved ease of use of growth hormone delivery devices and long-acting growth hormone formulations are now being developed. Flexpro, approved by the US Food and Drug Administration in March 2010, is the most recent pen device developed by Novo Nordisk A/S to deliver Norditropin. It is a multidose, premixed, preloaded, disposable pen device that requires relatively less force to inject and does not require refrigeration after initial use.

Uses and dosage :

The pen device must be refrigerated prior to first use, but after initial use, the pen devices can then either be stored outside of the refrigerator (at up to 77°F) for use within three weeks, or in the refrigerator (between 36°F and 46°F) for use within four weeks. The pen device is based on a spring mechanism that allows medication to be delivered by continuous depression of the dose button with negligible force. A different clicking sound alerts the patient to the dialing direction and an audible end-of-dose click confirms dose delivery. In addition, to improve ease of use in patients requiring large doses of growth hormone, the device is suitable for injecting doses up to 8 mg (15 mg Norditropin FlexPro. Small dose increments of 0.025 mg, 0.05 mg, and 0.1 mg provides the opportunity for finer dose adjustments, resulting in less product wastage and consequently saves cost.42 The Norditropin Flexpro pen device can also be used with a NovoFine needle, which is the shortest, sharpest and thinnest commercially available needle to reduce injection pain, with the 6 mm needles reported to reduce the rate of intramuscular deposition of drug significantly compared with the 12 mm needles.43 For patients with needle anxiety, there is the option of using the NovoFine Autocover, which hides the needle by a shield before, during, and after injections, retracts during each injection, and then covers the needle again.


Side effects:

serious allergic reactions. Get medical help right away if you have the following symptoms: swelling of your face, lips, mouth or tongue, trouble breathing, skin rashes, redness or swelling, dizziness or fainting, fast heartbeat or pounding in your chest, or sweating.
decrease in hormone called cortisol
decrease in thyroid hormone levels.
hip and knee pain or a limp in children (slipped capital femoral epiphysis).
worsening of pre-existing curvature of the spine (scoliosis).
middle ear infection, hearing or ear problems in patients with Turner syndrome.
redness, itching and tissue weakness in the area of skin you inject.
increase in phosphorus, alkaline phosphatase, and parathyroid hormone levels in your blood.

The most common side effects of Norditropin include:
headaches, muscle pain, joint stiffness, high blood sugar (hyperglycemia), and sugar in your urine (glucosuria).



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